Heart failure affects more than 25million people every year. Out of them hardly 20-30% people are able to get a heart transplant. That means most of the people suffering from heart failure won’t get a new one for survival. But there is a good news for them or atleast a ray of hope.
Scientists from Massachusetts General Hospital and Harvard Medical school grew a heart using stem cells then shocked it with an electric current to bring it to life.
In addition, researchers from Tel Aviv University have “printed” the world’s first 3D vascularized engineered heart using a patient’s own cells.
This all is done by using the Skin cells and around 73 donor hearts which were deemed unfit for the transplantation.
This is how it was done:
They first converted the skin cells into the pluripotent stem cells, then made them transform into two types of cardiac cells.
Next, they mimicked the environment a human heart would typically grow within and infused the cardiac cells with a nutrient solution that facilitated growth. They left the cells there for two weeks.
After the two weeks, they shocked the hearts with electricity and it began beating.
The study has been published in Circulation Research.
In another achievement, scientists at Tel Aviv University printed world’s first 3D heart which completely matches the biological properties of the patient who donated the cells.
In statement, they said –
“This is the first time anyone anywhere has successfully engineered and printed an entire heart replete with cells, blood vessels, ventricles and chambers…This heart is made from human cells and patient-specific biological materials. In our process these materials serve as the bioinks, substances made of sugars and proteins that can be used for 3D printing of complex tissue models. People have managed to 3D-print the structure of a heart in the past, but not with cells or with blood vessels. Our results demonstrate the potential of our approach for engineering personalized tissue and organ replacement in the future… At this stage, our 3D heart is small, the size of a rabbit’s heart. But larger human hearts require the same technology.”
The goal is to eventually grow an entire human heart that is capable of being transplanted.
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