A pill we take for everyday pains could also be reducing fertility in men.
Ibuprofen has a negative impact on the testicles of young men, a study published in the journal Proceedings of the National Academy of Sciences found. When taking ibuprofen in doses commonly used by everyone, a small sample of young men developed a hormonal condition that is linked to reduced fertility.
This medicine is present in various common brands that we take on a daily basis like Combiflam, Brufen, Advil, Motrin .
Their early experiments, published in several papers, showed that when taken during pregnancy, this mild medicine affected the testicles of male babies.
Testicles not only produce sperm, they secrete testosterone, the primary male sex hormone.
Ibuprofen is "anti-androgenic," meaning they disrupt male hormones, explained David M. Kristensen, study co-author.
It increase the likelihood that male babies would be born with congenital malformations, Kristensen noted.
Thus pregnant and nursing women should always ask a health professional before using medicines.
The research team recruited 31 male volunteers between the ages of 18 and 35. For the men taking ibuprofen daily for 14 days, their luteinizing hormones -- which are secreted by the pituitary gland and stimulate the testicles to produce testosterone -- became coordinated with the level of ibuprofen circulating in their blood. At the same time, the ratio of testosterone to luteinizing hormones decreased, a sign of dysfunctional testicles.
This hormonal imbalance produced compensated hypogonadism, a condition associated with impaired fertility, depression and increased risk for cardiovascular events, including heart failure and stroke.
"Larger clinical trials are warranted, this is timely work that should raise awareness of medication effects on men and potentially their offspring."
We should try to minimize the use of every medicine, no matter which because in the end all of them are drugs and finding the side effects of medicines take decades. Thus medicine that might appear safe to us at this time might be discovered to have a lots of side effects many years later.
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