An HIV-positive man in London has become the second known adult to be cleared of the AIDS virus after he received a bone marrow transplant from an HIV resistant donor, his doctors said.
He received a Bone marrow stem cells transplant three years back from a donor with a rare genetic mutation that resists HIV infection - and more than 18 months after coming off antiretroviral drugs - highly sensitive tests still show no trace of the man’s previous HIV infection.
“There is no virus there that we can measure. We can’t detect anything,” said Ravindra Gupta, a professor and HIV biologist who co-led a team of doctors treating the man.
The case is a proof of the concept that scientists will one day be able to end AIDS, the doctors said, but does not mean a cure for HIV has been found.
Gupta described his patient as “functionally cured” and “in remission”, but cautioned: “It’s too early to say he’s cured.”
The man is being called “the London patient”, in part because his case is similar to the first known case of a functional cure of HIV - in an American man, Timothy Brown, who became known as the Berlin patient when he underwent similar treatment in Germany in 2007 which also cleared his HIV.
Brown, who had been living in Berlin, has since moved to the United States and, according to HIV experts, is still HIV-free.
Some 37 million people worldwide are currently infected with HIV and the AIDS pandemic has killed around 35 million people worldwide since it began in the 1980s. Scientific research into the complex virus has in recent years led to the development of drug combinations that can keep it at bay in most patients.
Gupta, now at Cambridge University, treated the London patient when he was working at University College London. The man had contracted HIV in 2003, Gupta said, and in 2012 was also diagnosed with a type of blood cancer called Hodgkin’s Lymphoma.
In 2016, when he was very sick with cancer, doctors decided to seek a transplant match for him. “This was really his last chance of survival,”.
The donor - who was unrelated - had a genetic mutation known as ‘CCR5 delta 32’, which confers resistance to HIV.
The transplant went relatively smoothly, Gupta said, but there were some side effects, including the patient suffering a period of “graft-versus-host” disease - a condition in which donor immune cells attack the recipient’s immune cells.
Title – A title can be anything from a question, a heading of the article, or even the main topic about which you are publishing the post.
Description – It is explaining and adding the details about the topic you are posting. If you are asking a Question, then adding details is not necessary.
Photo, Video – You can attach a photo related to your post or can even publish a YOUTUBE video.
Sharing – Your name gets automatically attached behind the title of the article when you share is on Facebook or other platforms.
Eg: If a user John Watson have posted an article with the Title “How to handle Migraine without medicines?” and then if anyone share it on Facebook, the title will be like this :
“How to handle Migraine without medicines?”- John Watson
Themes of publishing or asking – You can publish from various themes that we mentioned and if any topic is missing among them, you can still post anything related to the Health. Healthcare is the only broad theme.