Alizapride

Generic Name: Alizapride

Alizapride is a dopamine antagonist with prokinetic and antiemetic effects used in the treatment of nausea and vomiting, including postoperative nausea and vomiting.

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The anti-emetic action of Alizapride is due to its antagonist activity at D2 receptors in the chemoreceptor trigger zone (CTZ) in the central nervous system (CNS)—this action prevents nausea and vomiting triggered by most stimuli.

Alizapride is a dopamine antagonist with prokinetic and antiemetic effects used in the treatment of nausea and vomiting, including postoperative nausea and vomiting.

Drowsiness, dizziness, headache, diarrhea, extrapyramidal symptoms, amenorrhea, galactorrhea may occur while using this drug.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Oral – Nausea and vomiting

Adult: 75-300 mg/day in divided doses.

Child: 5 mg/kg/day.

Parenteral – Nausea and vomiting associated with cancer chemotherapy

Adult: 2-5 mg/kg/day given by IV/IM in 2 divided doses. 1st dose to be administered 30 min before and the next dose 4-8 hr after admin of cytotoxic drug.

For highly emetogenic regimens requiring doses >5 mg/kg, dose may be given via IV infusion over 15 min every 2 hr for 5 doses. Start infusion 30 min before admin of cytotoxic drug.

Max: 4.5 g/course of chemotherapy.

What drugs may interact with alizapride?

Alizapride may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with alizapride?

Alizapride may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with alizapride?

Alizapride may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Alizapride is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store alizapride in the bathroom or the freezer. There may be different brands of alizapride that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of alizapride or other medications.
  • You have any other illnesses, disorders, or medical conditions.

Pheochromocytoma, Parkinson’s disease, conditions where activation of GI motility is contraindicated (e.g. GI perforation or sub-occlusion).

Caution in renal impairment. May impair ability to drive or operate machinery.

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