Anastrozole (Arimidex)

Generic Name: Anastrozole

Anastrozole, sold under the brand name Arimidex among others, is a medication used in addition to other treatments for breast cancer. Specifically it is used for hormone receptor-positive breast cancer. It has also been used to prevent breast cancer in those at high risk. It is taken by mouth.


Anastrozole.svg

Common side effects include hot flushes, altered mood, joint pain, and nausea. Severe side effects include an increased risk of heart disease and osteoporosis. Use during pregnancy is known to harm the baby. Anastrozole is in the aromatase-inhibiting family of medications. It works by blocking the creation of estrogen.

No health feed found.

Anastrozole works by reversibly binding to the aromatase enzyme, and through competitive inhibition blocks the conversion of androgens to estrogens in peripheral (extragonadal) tissues.

Anastrozole comes as a tablet to take by mouth. It is usually taken once a day with or without food. Take anastrozole at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take anastrozole exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

You may need to take anastrozole for several years or longer. Continue to take anastrozole even if you feel well. Do not stop taking anastrozole without talking to your doctor.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

Anastrozole may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • weakness
  • headache
  • hot flashes
  • sweating
  • stomach pain
  • nausea
  • vomiting
  • loss of appetite
  • constipation
  • diarrhea
  • heartburn
  • weight gain
  • joint, bone, or muscle pain
  • breast pain
  • mood changes
  • depression
  • difficulty falling asleep or staying asleep
  • nervousness
  • dizziness
  • vaginal bleeding
  • vaginal dryness or irritation
  • pain, burning, or tingling in the hands or feet
  • dry mouth
  • hair thinning

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

  • chest pain
  • sore throat, cough, fever, chills, swollen glands, or other signs of infection
  • swelling, redness, or warmth in hand or arm
  • difficult, painful, or urgent urination
  • blurred vision or vision changes
  • yellowing of the skin or eyes
  • pain in the upper right part of the stomach
  • skin lesions, ulcers, or blisters
  • rash
  • hives
  • itching
  • shortness of breath
  • difficulty swallowing or breathing
  • swelling of the eyes, face, lips, tongue, throat, arms, hands, feet, ankles, or lower legs

Anastrozole may cause or worsen osteoporosis. It can decrease the density of your bones and increase the chance of broken bones and fractures. Talk to your doctor about the risks of taking this medication and to find out what you can do to decrease these risks.

Anastrozole may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

Anastrozole is usually taken once per day. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

You may take anastrozole with or without food.

You may need to keep taking this medication for up to 5 years. Follow your doctor's instructions.

Store at room temperature away from moisture and heat.

There may be an interaction between anastrozole and any of the following: any estrogen-containing medications. aripiprazole. dofetilide.

Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your body's response to anastrozole.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Anastrozole can cause a severe allergic reaction. Symptoms may include: trouble breathing. swelling of your throat or tongue.

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