Anistreplase

Generic Name: Anistreplase

Anistreplase is commonly used for preventing blood from clotting. Studies have shown this medication to be effective in reducing the risk of death following an acute heart attack.

Human tissue plasminogen activator, purified, glycosylated, 527 residues purified from CHO cells. Eminase is a lyophilized (freeze-dried) formulation of anistreplase, the p-anisoyl derivative of the primary Lys-plasminogen-streptokinase activator complex (a complex of Lys-plasminogen and streptokinase). A p-anisoyl group is chemically conjugated to a complex of bacterial-derived streptokinase and human Plasma-derived Lys-plasminogen proteins.
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Anistreplase cleaves the Arg/Val bond in plasminogen to form plasmin. This in turn leads to the degradation of blood clots. It is a complex of purified human plasminogen and bacterial streptokinase that has been acylated to protect the enzyme's active site. When the drug is administered, the acyl group gets hydrolyzed, thereby freeing the activator complex. It converts plasminogen to plasmin, which in turn degrades fibrin (blood clots) to fibrin split products.

Anistreplase is used in the treatment of:

  • Myocardial Infarction
  • Pulmonary Embolism

Bleeding and irregular heart rhythms may occur as a result of this drug. You will be monitored closely for signs of these effects.

Notify your doctor of: itching, flushing, skin rash, fever, chills, headache, nausea, sweating, dizziness, muscle aches or tremor.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Take anistreplase exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The Anistreplase dose your doctor recommends will be based on the following (use any or all that apply):

  • the condition being treated
  • other medical conditions you have
  • other medications you are taking
  • how you respond to this medication
  • your weight
  • your height
  • your age
  • your gender

Anistreplase is available in the following doses:

  • Anistreplase 30 Units Intravenous Powder For Injection

What drugs may interact with anistreplase?

Anistreplase may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products that may interact with this drug are:

  • Corticosteroids (e.g., prednisone)
  • Aspirin (or drugs related to aspirin)
  • “blood thinners” (e.g., warfarin, heparin)
  • Aminocaproic acid
  • Drugs used for high blood pressure
  • Valproic acid
  • Injectable cephalosporins
  • Drugs used for arthritis (NSAID such as ibuprofen and naproxen)
  • Sulfinpyrazone

Does food or alcohol interact with anistreplase?

Anistreplase may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with anistreplase?

Anistreplase may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

If you miss a dose of anistreplase, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of anistreplase or other medications.
  • You have any other illnesses, disorders, or medical conditions.

This drug should not be used when the following conditions are present: bleeding, blood vessel abnormalities, brain tumor, history of stroke, recent surgery, extremely high blood pressure (200/120 or higher).

This drug should be used with caution when the following conditions exist: childbirth within the last 10 days, blood clotting problems, endocarditis, recent retinal bleeding, recent gastrointestinal or urinary tract bleeding, ulcers, very high blood pressure (180/110), a recent invasive procedure, if you have ever had a synthetic graft placed (knitted Dacron), heart abnormalities.

This medication should be used during pregnancy only if clearly needed. Discuss the risks and benefits with your doctor. 

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