Cefixime

Cefixime is an antibiotic useful to treat a number of bacterial infections. This includes otitis media, strep throat, pneumonia, urinary tract infections, gonorrhea, and Lyme disease. For gonorrhea typically only one dose is required. In the United States it is a second line treatment to ceftriaxone for gonorrhea. It is taken by mouth.

Common side effects include diarrhea, abdominal pain, and nausea. Serious side effects may include allergic reactions and Clostridium difficile diarrhea. It is not recommended in people with a history of a severe penicillin allergy. It appears to be relatively safe during pregnancy. It is in the third generation cephalosporin class of medications. It works by disrupting the bacteria's cell wall resulting in its death.

Cefixime was approved for medical use in the United States in 1989. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. It is not available as a generic medication in the United States. In the United States a course of treatment costs about 100 to 200 USD as of 2015.

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  • Urinary Tract Infection

    Cefixime is used in the treatment of urinary tract infection caused by E. coli, Pseudomonas aeruginosa, Enterococci, and Klebsiella pneumoniae. `

  • Ear Infection (Otitis Media)

    Cefixime is used in the treatment of otitis media caused by Streptococcus pneumoniae, E. coli, Pseudomonas aeruginosa, and Klebsiella pneumoniae.

  • Tonsilitis/Pharyngitis

    Cefixime is used in the treatment of Tonsillitis/Pharyngitis caused by Streptococcus pneumoniae, Haemophilus influenzae, and some fungal infections.

  • Bronchitis

    Cefixime is used in the treatment of bronchitis caused by Streptococcus pneumoniae, Haemophilus influenzae, and some Mycoplasma pneumoniae.

  • Gonococcal infection

    Cefixime is used in the treatment of Gonococcal infection caused by Neisseria gonorrhoeae.

  • Diarrhea

  • Abdominal pain

  • Dark or clay colored stools

  • Swelling of face, lips, eyelids, tongue, hands and feet

  • Dizziness

  • Acid or sour stomach

  • Excessive air or gas in stomach

  • Heartburn

  • Indigestion

  • Redness of skin

  • Missed Dose

    The missed dose should be taken as soon as possible. It is advisable to skip the missed dose if it is already time for your next scheduled dose. Do not use extra medicine to make up for the missed dose.

  • Overdose

    Seek emergency medical treatment or contact the doctor in case of an overdose.

All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.

Interaction with Alcohol

  • Description

     - Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Instructions

     - Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Interaction with Medicine

  • Amikacin

  • Chloramphenicol

  • Nifedipine

  • Warfarin

  • Ethinyl Estradiol

  • Cholera Vaccine

  • Furosemide

Disease interactions

  • Colitis

    This medicine should be used with extreme caution in patients having a history of gastrointestinal diseases, particularly colitis, due to the increased risk of worsening of the patient's condition. Report any incidence of severe diarrhea, abdominal pain, and blood in stools to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

  • Renal Diseases

    Cefixime should be used with caution in patients with renal diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative might be required in some cases based on the clinical condition.

Food interactions

  • Information not available.

Lab interactions

  • Coombs test

    Report the use of this medicine to the doctor if you are undergoing this test. A false positive result may be obtained if this test is performed while taking this medicine. Do not stop the use of any medicine without consulting your doctor.

  • Urine ketones test

    Report the use of this medicine to the doctor if you are undergoing this test. A false positive result may be obtained if this test is performed while taking this medicine. Do not stop the use of any medicine without consulting your doctor.

Take Cefixime with or without food. Do not take in larger amounts than advised/prescribed. Consult the doctor if you experience any undesirable effects. Ensure that the course of treatment is completed. Do not stop the use of this medicine without consulting your doctor.

Warnings for special population

  • Pregnancy - This medicine is not recommended for use in pregnant women unless necessary and the potential benefits outweigh the risks involved. Consult your doctor before using this medicine.

  • Breast-feeding - This medicine is not recommended for use in breastfeeding women unless absolutely necessary. If the medicine is used, close monitoring of the infant for any undesired effects is necessary.

General warnings

  • Allergy - This medicine is not recommended for use if you have a known allergy to Cefixime or Beta-lactam Antibiotics. Seek immediate medical attention if you experience any allergic symptoms like rash, itching, nausea or vomiting, swelling of lips, hands, and feet.

  • Clostridium difficile-associated Diarrhea - Discontinue the use of this medicine as per the doctor's instructions if severe diarrhea occurs after receiving Cefixime. This medicine may cause an imbalance in the microbial flora of the large intestine, decreasing the gut-friendly bacteria and promoting the growth of a bacteria called Clostridium difficile, resulting in severe diarrhea.

  • Bleeding disorders - This medicine should be used with caution in patients with bleeding disorders due to the increased risk of excessive bleeding. Regular monitoring of prothrombin time is necessary in such cases. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

  • Kidney disease - This medicine should be used with caution in patients with an impaired kidney function due to the increased risk of severe adverse effects. Appropriate dose adjustments are to be made based on the CrCl or eGFR.

  • Use in pediatrics - This medicine is not recommended for use in children less than 6 months of age since the safety and efficacy of use are not clinically established in this particular age group.

  • Drug resistance - Usage of Cefixime without sufficient proof or suspicion of a bacterial infection should be avoided. Irrational dosing might fail in providing the benefits and even cause toxicity. It may also increase the risk of development of bacteria that are drug resistant.

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