Miconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Miconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis.
Miconazole is mainly used externally for the treatment of ringworm including jock itch and athlete's foot. Internal application is used for oral or vaginal thrush (yeast infection). The oral gel may also be used for the lip disorder angular cheilitis.
Check with your doctor as soon as possible if any of the following side effects occur:
Common side effects may include:
Other side effects not
listed may also occur in some patients. If you notice any other effects, check
with your healthcare professional.
Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.
The usual dose of this medicine is one tablet each morning for 14 days in a row.
Brush your teeth before putting in a buccal tablet. Make sure your hands are dry before handling the tablet.
The miconazole buccal tablet should be placed against your upper gum, just above your incisor tooth. Incisor teeth are located on the right and left sides of your two front teeth.
Place the rounded side of the tablet against your gum. Close your mouth and press your finger gently against the side of your cheek for 30 seconds to make sure the tablet stays in place.
Do not chew or swallow the buccal tablet. Leave it in place until the next morning. Avoid touching or pressing the tablet while it is in place.
You may eat and drink normally while the tablet is in place, but avoid chewing gum.
During the first 6 hours after placing a buccal tablet in your mouth, if the tablet comes loose try putting it back into place. If the tablet won't stay in place, throw it away and put in a new tablet. If you accidentally swallow a tablet within the first 6 hours of wearing time, drink a full glass of water and put in a new tablet.
After the first 6 hours, if a tablet comes loose or you accidentally swallow it, do not put in a new tablet. Wait until the next morning to put in a new tablet.
If any pieces of the tablet remain in your mouth the next morning, rinse your mouth with water before using a new tablet.
Place the new tablet on the side of your upper gum that is opposite from the side you used the day before. Switch sides of your mouth each morning when using a new tablet.
Call your doctor if your symptoms do not improve, or if they get worse.
Store at room temperature
away from moisture and heat.
Avoid chewing gum, swishing liquid in your mouth, or hitting the tablet while brushing your teeth.
Avoid wearing an upper denture if it gets in the way of the buccal tablet.
Tell your doctor about all your current medicines and any you start or stop using, especially:
This list is not
complete. Other drugs may interact with miconazole buccal, including
prescription and over-the-counter medicines, vitamins, and herbal products. Not
all possible interactions are listed in this medication guide.
When miconazole is used to treat certain types of fungus infections of the skin, an occlusive dressing (airtight covering, such as kitchen plastic wrap) should not be applied over this medicine. To do so may cause irritation of the skin. Do not apply an occlusive dressing over this medicine unless you have been directed to do so by your doctor.
To help clear up your infection
completely, keep using this medicine for the full time of treatment, even if
your condition has improved. Do not miss any doses.
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Although there is no specific information comparing use of topical miconazole in children with use in other age groups, this medicine is not expected to cause different side effects or problems in children than it does in adults.
Many medicines have not
been studied specifically in older people. Therefore, it may not be known
whether they work exactly the same way they do in younger adults. Although
there is no specific information comparing use of topical miconazole in the
elderly with use in other age groups, this medicine is not expected to cause
different side effects or problems in older people than it does in younger