Procaine benzylpenicillin

Generic Name: Procaine benzylpenicillin

Procaine benzylpenicillin also known as penicillin G procaine, is an antibiotic useful for the treatment of a number of bacterial infections. Specifically it is used for syphilis, anthrax, mouth infections, pneumonia, diphtheria, cellulitis, and animal bites. It is given by injection into a muscle.

Side effects include pain at the site of injection, blood clotting problems, seizures, and allergic reactions including anaphylaxis. When used to treat syphilis a reaction known as Jarisch-Herxheimer may occur. It is not recommended in those with a history of penicillin allergy or procaine allergy. Use during pregnancy and breastfeeding is relatively safe. Procaine benzylpenicillin is in the penicillin and beta lactam family of medications. It works via benzylpenicillin and results in bacterial death. Procaine makes the combination long acting.

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It is a form of penicillin which is a combination of bernzylpenicillin and the local anaesthetic agent procaine. Following deep intramuscular injection, it is slowly absorbed into the circulation and hydrolysed to benzylpenicillin — thus it is used where prolonged low concentrations of benzylpenicillin are required.

Specific indications for procaine penicillin include:

  • Syphilis
    • In the United States, Bicillin C-R (a injectable suspension which 1.2 million units of benzathine penicillin and 1.2 million units of procaine penicillin per 4 ml) is not recommended for treating syphilis, since it contains only half the recommended dose of benzathine penicillin. Medication errors have been made due to the confusion between Bicillin L-A & Bicillin C-R. As a result, changes in product packaging have been made; specifically, the statement "Not for the Treatment of Syphilis" has been added in red text to both the Bicillin CR and Billin CR 900/300 syringe labels.
  • Respiratory tract infections where compliance with oral treatment is unlikely
  • Alongside Pen V and Erythromycin, Bicillin C-R is used to treat strep throat, given as one IM injection
  • Cellulitis, erysipelas
  • Procaine penicillin is also used as an adjunct in the treatment of anthrax

At high doses procaine penicillin can cause seizures and CNS abnormalities due to procaine present in it.

Procaine penicillin is given as an injection into a muscle. Your doctor, nurse, or other healthcare provider will give you this injection. You may be shown how to inject your medicine at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes.

Procaine penicillin must be injected slowly into a muscle of the buttock or upper thigh.

Do not inject the medication into a vein or life-threatening side effects could result.

Your procaine penicillin injections should be given at evenly spaced intervals.

Use this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Procaine penicillin will not treat a viral infection such as the common cold or flu.

Call your doctor if your infection does not improve, or if it gets worse while using procaine penicillin.

Use each disposable needle only one time. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

This medication can cause you to have unusual results with certain lab tests, including tests to check for glucose (sugar) in the urine. Tell any doctor who treats you that you are using procaine penicillin.

After you have finished your treatment with procaine penicillin, your doctor may want to do tests to make sure your infection has completely cleared up.

Store this medication in the refrigerator. Do not freeze. Do not use the mixed medication if it has changed colors or has any particles in it.

Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include mood changes, agitation, confusion, and seizure (convulsions).

Use the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up the missed dose.

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, stop using this medication and call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.

Do not receive a "live" vaccine such as typhoid vaccine, cholera vaccine, or BCG (Bacillus Calmette and Guérin) vaccine.

Tell your doctor about all other medications you use, especially:

  • probenecid (Benemid);
  • a blood thinner such as warfarin (Coumadin);
  • a diuretic (water pill) such as furosemide (Lasix), hydrochlorothiazide (HCTZ, HydroDiuril, Hyzaar, Lopressor HCT, Vasoretic, Zestoretic), and others;
  • methotrexate (Rheumatrex, Trexall);
  • a tetracycline antibiotic, such as demeclocycline (Declomycin, Ledermycin), doxycycline (Adoxa, Doryx, Vibramycin, Periostat), minocycline (Minocin), or tetracycline (Ala-Tet, Sumycin, Tetracap); or
  • NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Motrin, Advil), diclofenac (Cataflam, Voltaren), etodolac (Lodine), indomethacin (Indocin), naproxen (Aleve, Naprosyn), meloxicam (Mobic), piroxicam (Feldene), and others.

This list is not complete and there may be other drugs that can interact with procaine penicillin. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Procaine penicillin is an antibiotic that fights bacteria in your body.

Procaine penicillin is used to treat many different types of infections caused by bacteria, including syphilis (a sexually transmitted disease).

  • Anaphylaxis. SERIOUS AND OCCASIONALLY FATAL HYPERSENSITIVITY(ANAPHYLACTIC) REACTIONS HAVE BEEN REPORTED IN PATIENTS ON PENICILLIN THERAPY. ...
  • Pseudomembranous Colitis. ...
  • Procaine Reactions. ...
  • Method of Administration.

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